Opossums are fascinating creatures with an array of interesting attributes. One of the most remarkable things about these marsupials is their distinct and powerful immune system. Opossums can help us better understand diseases and immunology, which makes them incredibly valuable creatures. Opossums have evolved to fend off potential predators and diseases, making them one of the few mammals with a high rate of resistance against rabies. They have a unique antibody against the virus that is not found in other species, as well as an innovative way to produce it quickly. This immune system is stronger than many other animals. Lastly, opossums have other adaptive behaviors that make them suitable to their environment. In response to any potential threat, they have the unique ability to “play possum,” meaning they become completely still and withdrawn. They also possess a special technique to escape predators known as hind-leg paralysis. This is when the opossum uses its hind legs as a decoy, which gives it just enough time to flee before the predator can react. Opossums are intriguing animals with remarkable qualities, from their resilient immune system to their ability to “play possum.” Their fascinating features and use to humans make them an incredibly valuable species in the animal kingdom.